GSK872, Necroptosis inhibitor (ab254395)
Key features and details
- Highly potent, selective RIP3 inhibitor
- CAS Number: 1346546-69-7
- Purity: > 98%
Soluble in DMSO up to 50mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
GSK872, Necroptosis inhibitor -
Description
Highly potent, selective RIP3 inhibitor -
Alternative names
- GSK'872
- GSK2399872A
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Biological description
Highly potent, selective receptor interacting protein 3 (RIP3) inhibitor (IC50 = 1.3nM). Selectivty for RIP3 is over 100-fold more compared to other kinases. At high concentrations (3-10μM) can induce Caspase 8-mediated apoptosis. Increases HIF-1a expression after ischaemic injury in vivo. Blocks necroptosis in primary human neutrophils, TNF-induced necroptosis in HT-29 cells and inhibits TLR3- and DAI-induced death in vitro.
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Purity
> 98% -
General notes
Solutions in DMSO can be stored for up to 1 month.
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CAS Number
1346546-69-7 -
Chemical structure
Properties
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Chemical name
N-(6-Propan-2-ylsulfonylquinolin-4-yl)-1,3-benzothiazol-5-amine
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Molecular weight
383.48 -
Molecular formula
C19H17N3O2S2 -
PubChem identifier
54674134 -
Storage instructions
Shipped at Room Temperature. Store at -20°C. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO up to 50mM
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Handling
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC(C)S(=O)(=O)C1=CC2=C(C=CN=C2C=C1)NC3=CC4=C(C=C3)SC=N4 -
Source
Synthetic
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
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SDS download
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Datasheet download
References (0)
ab254395 has not yet been referenced specifically in any publications.