Methylation-specific Antibodies
BioVision is excited to offer a wide variety of antibodies to detect protein methylation.
Methylation is a type of post-translational modification of the protein, wherein methyl group(s) are added either at the lysine or arginine residue. One or two methyl groups may be added to the arginine residue. Both the methyl groups may be added either on a single nitrogen terminal (asymmetric methyl) or one on each nitrogen terminal (symmetric methyl) by peptidylarginine methyltransferases (PRMTs). On the other hand, lysine residues may have either one, two, or three methyl groups added by lysine methyltransferases (KMTs). Methylation occurs on histone as well as non-histone proteins (e.g. transcription factors) and plays important roles in biological functions such as transcription of genes, synthesis of proteins, and cell signaling pathways. Dysfunction of the methylation process is associated with diseases such as cancer, neurodegenerative diseases, and cardiovascular diseases. Hence, to help customers in their study on methylated proteins, BioVision offers a number of methylation-specific antibodies.
Features & Benefits
• Highly specific for methylated proteins
• No cross-reactivity with acetylated proteins
• Highly pure
• Available in monoclonal and polyclonal formats
• Highly validated in applications such as Western blot, Dot blot, CHIP, ICC etc.
