Procathepsin S, human recombinant

A lysosomal cysteine protease participating in the degradation of antigenic proteins to peptides
Catalog #: 7525 | abID: ab285881

Product Details

abID ab285881
Alternate Name CTSS
Gene Symbol CTSS
Gene ID 1520
Accession # P25774
Source E. coli
Appearance Lyophilized
Physical Form Description Lyophilized from proprietary buffer.
Molecular Weight 38.1 kDa (17-331 aa + N-terminal poly-his tag)
Purity by SDS-PAGE ≥90%
Biological Activity Biovision’s Procathepsin S can be auto-catalytically activated to mature Cathepsin S (~24 kDa) by adding an equal volume of 0.2 M NaOAc, 5 mM EDTA pH 4.0 containing fresh 5 mM DTT at room temperature (RT). The enzyme is fully activated within 2-3 hrs. of
Reconstitution Instructions Reconstitute in 25 mM Na2HPO4, 500 mM NaCl (pH 7.0) to 0.5-1 mg/ml
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans


Cathepsin S (CTSS) is a lysosomal cysteine protease of the papain family and may participate in the degradation of antigenic proteins to peptides for presentation on MHC class II molecules. CTSS is synthesized as inactive precursor of 331 amino acids consisting of a 15-aa signal peptide, a propeptide of 99 aa, and a mature polypeptide of 217 aa. It is activated in the lysosomes by a proteolytic cleavage of the propeptide. The deduced amino acid sequence contains only one potential N-glycosylation site located in the propeptide. Compared with the abundant cathepsins B, L and H, cathepsin S shows a restricted tissue distribution, with highest levels in spleen, heart, and lung. In addition, evidences indicate that cathepsin S generates amyloid beta-peptide from amyloidogenic fragments of amyloid precursor protein (APP) in the endosomal/lysosomal compartment, and is implicated in the pathogenesis of Alzheimer’s disease and Down Syndrome.

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