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Procathepsin K, rat recombinant

Predominant proteinase responsible for the resorption of the bone matrix.
Catalog #: 1029
SKU-Size Size Price Qty
1029-1000 1 mg
$7,950.00
1029-10 10 μg
$239.00
1029-50 50 μg
$895.00
More Sizes Get Quote

Product Details

Alternate Name CTSK, CTSO, CTSO3
Gene Symbol CATK
Gene ID 25425
Accession # P00786
Source E. coli.
Appearance Liquid
Physical Form Description 1 mg/ml solution in 25 mM Na2HPO4 and 500 mM NaCl (pH 7.0).
Molecular Weight 35.4 kDa
Purity by SDS-PAGE ≥95%
Biological Activity The specific activity is >400 mU/mg (1U = 1 µmole/min/mg) as measured by Cathepsin K Activity Assay Kit (Catalog # K141-100)
Handling Centrifuge the vial prior to opening.
Storage Conditions -80°C
Shipping Conditions Dry Ice
USAGE For Research Use Only! Not to be used in humans

Details

Cathepsin K, a member of the papain cysteine proteinase family, is the predominant proteinase responsible for the resorption of the bone matrix. Cathepsin cleaves proteins such as collagen type I, collagen type II and osteonectin, thereby playing a role in bone remodeling and resorption in osteoporosis, osteolytic bone metastasis and rheumatoid arthritis (Bromme and Okamoto, 1995; Drake, F. et al 1996; Bossard et al, 1996). Cathepsin K is produced as an inactive proenzyme (35.4 kDa) that is converted to its mature active form (23.5 kDa) by proteolytic cleavage of its 99-amino-acid propeptide domain. The in-vitro processing of procathepsin K to mature cathepsin K is autocatalytic.


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