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Procathepsin K, mouse recombinant

Predominant proteinase responsible for the resorption of the bone matrix.
Catalog #: 1027
SKU-Size Size Price Qty
1027-10 10 μg
$239.00
1027-50 50 μg
$895.00
1027-1000 1 mg
$7,950.00
More Sizes Get Quote

Product Details

Alternate Name Cathepsin O, Cathepsin O2, Cathepsin X, CTSK, CTSO, CTSO2
Gene Symbol CATK
Gene ID 1513
Accession # P43235
Source E. coli.
Appearance Liquid
Physical Form Description 2.5 mg/ml solution in 25 mM Na2HPO4 and 500 mM NaCl (pH 7.0).
Molecular Weight 35.5 kDa
Purity by SDS-PAGE ≥95%
Handling Centrifuge the vial prior to opening.
Storage Conditions -80°C
Shipping Conditions Dry Ice
USAGE For Research Use Only! Not to be used in humans

Details

Cathepsin K is a member of the papain cysteine proteinase family and has been identified as the predominant proteinase responsible for the resorption of the bone matrix. The enzyme cleaves proteins such as collagen type I, collagen type II and osteonectin and therefore plays a role in bone remodeling and resorption in diseases such as osteoporosis, osteolytic bone metastasis and rheumatoid arthritis (Bromme and Okamoto, 1995; Drake, F. et al 1996; Bossard et al, 1996). Cathepsin K is synthesized as an inactive proenzyme (35.1 kDa) that is converted to its mature active form (23.6 kDa) by proteolytic cleavage of its 99-amino-acid propeptide domain. The in-vitro processing of procathepsin K to mature cathepsin K is autocatalytic.


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