Product Details
| Antibody Target | Procathepsin K |
|---|---|
| Alternate Name | CTSK, CTSO, CTSO3 |
| Host | Rabbit |
| Antibody Type | Polyclonal |
| Isotype | Rabbit IgG |
| Immunogen | Recombinant protein Procathepsin (19-329aa) (BV-M64) |
| Accession # | P43235 |
| Gene ID | 1513 |
| Appearance | Colorless liquid |
| Concentration | 0.5 mg/ml |
| Formulation | Supplied in PBS pH 7.2, containing 0.01% BSA, 50% glycerol, and 0.03% Proclin |
| Purification | Affinity Purified Antibody |
| Species Reactivity | Human |
| Application | Western blot |
| Positive Control | Western blot: Recombinant protein |
| Application & Usage | Western blot: ~1:200 |
| Handling | The antibody solution should be gently mixed before use. |
| Storage Conditions | -20 °C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
Cathepsin K, a member of the papain cysteine proteinase family is the predominant proteinase responsible for the resorption of the bone matrix. Cathepsin cleaves proteins such as collagen type I, collagen type II and osteonectin, thereby playing a role in bone remodeling and resorption in osteoporosis, osteolytic bone metastasis and rheumatoid arthritis (Bromme and Okamoto, 1995; Drake, F. et al 1996; Bossard et al, 1996). Cathepsin K is synthesized as an inactive proenzyme (35.1 kDa) that is converted to its mature active form (23.6 kDa) by proteolytic cleavage of its 99-amino-acid propeptide domain. The in-vitro processing of procathepsin K to mature cathepsin K is autocatalytic.
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