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Procathepsin K Antibody

Polyclonal Antibody to detect Procathepsin K in rat samples
Catalog #: 6661
SKU-Size Size Price Qty
6661-30T 30 µl
$89.00
6661-100 100 μl
$265.00
More Sizes Get Quote

Product Details

Antibody Target Procathepsin K
Alternate Name CTSK, CTSO, CTSO3
Host Rabbit
Antibody Type Polyclonal
Isotype Rabbit IgG
Immunogen Recombinant rat Procathepsin K (Cat # 1029)
Accession # P00786
Gene ID 25425
Appearance Colorless liquid
Concentration 0.5 mg/ml
Formulation 100 µg (0.5 mg/ml) of antibody in PBS pH 7.2 containing 0.01 % BSA, 0.01 % thimerosal, and 50 % glycerol.
Purification Affinity Purified Antibody
Species Reactivity Rat
Application Western blot
Positive Control Western Blot: Recombinant protein
Application & Usage Western blot: 1-4 µg/ml.
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Cathepsin K, a member of the papain cysteine proteinase family, is the predominant proteinase responsible for the resorption of the bone matrix. Cathepsin cleaves proteins such as collagen type I, collagen type II and osteonectin, thereby playing a role in bone remodeling and resorption in osteoporosis, osteolytic bone metastasis and rheumatoid arthritis (Bromme and Okamoto, 1995; Drake, F. et al 1996; Bossard et al, 1996). Cathepsin K is produced as an inactive proenzyme (35.4 kDa) that is converted to its mature active form (23.5 kDa) by proteolytic cleavage of its 99-amino-acid propeptide domain. The in-vitro processing of Procathepsin K to mature Cathepsin K is autocatalytic.


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