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ProBDNF, human recombinant

Neuronal apoptosis inducer
Catalog #: 4273

In stock

SKU-Size Size Price Qty
4273-10 10 μg
$175.00
4273-50 50 μg
$475.00
4273-1000 1 mg
$3,800.00
More Sizes Get Quote

Product Details

Alternate Name Brain-derived neurotrophic factor (BDNF) (Abrineurin)
Gene Symbol BDNF
Gene ID 627
Accession # P23560
Source E. coli
Appearance Lyophilized protein
Physical Form Description Lyophilized from a 0.2 μm filtered solution of 20 mM PB and 250 mM NaCl, pH 7.2.
Molecular Weight ~26 kDa
Purity by SDS-PAGE ≥95%
Endotoxin Level <0.1 ng/μg (1 IEU/μg)
Reconstitution Instructions Dissolve in 1x PBS (It is not recommended to reconstitute to a final concentration less than 100μg/ml.). This can further be diluted to other aqueous buffers.
Amino Acid Sequence Recombinant Human precursor form of Brain-derived neurotrophic factor produced in E. coli is a non-glycosylated polypeptide chain containing 2X229 amino acids as a homodimer and having a molecular mass of 52 kDa. The sequence of the first five N-terminal
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans

Details

Precursor form of Brain-derived neurotrophic factor (Pro-BDNF) interacts preferentially with the pan-neurotrophin receptor p75 (p75NTR) and vps10p domain-containing receptor sortilin and induces neuronal apoptosis, whereas mature BDNF selectively binds with high affinity to the TrkB kinase receptor and promotes the survival, growth and differentiation of neurons. As proneurotrophins and mature neurotrophins elicit opposite biological effects, Pro-BDNF cleavage in the neuronal system is regulated in a specific and cell-context dependent manner. Pro-BDNF plays important role in negative regulation of neurotrophic actions in the brain.


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