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Pro-Urokinase, human recombinant

After activation, forms Urokinase, which is a serine protease
Catalog #: 7695

In stock

SKU-Size Size Price Qty
7695-10 10 µg
$140.00
7695-50 50 µg
$395.00
7695-500 500 µg
$1,495.00
More Sizes Get Quote

Product Details

Alternate Name Single chain Urokinase-type plasminogen activator (scuPA), Urokinase-type Plasminogen Activator uPA, PLAU.
Gene Symbol PLAU
Gene ID 5328
Accession # P00749
Source E. coli.
Appearance Lyophilized powder
Physical Form Description Lyophilized from proprietary buffer.
Molecular Weight 49.3 kDa
Purity by SDS-PAGE ≥90%
Biological Activity >1200 mU/mg (1 U = Digestion of 1 µmole of Z-GGR-AMC substrate in 1 min at 37ºC.)
Reconstitution Instructions Briefly spin down the vial and reconstitute in water to 0.5-1 mg/ml and store at –80°C.
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans

Details

Urokinase or Urokinase-type plasminogen activator (uPA) is a serine protease (EC 3.4.21.73). It is secreted as a single-chain zymogen, pro-Urokinase, possessing little or no intrinsic enzymatic activity. The single chain zymogen is converted into the active two chain enzyme (tcuPA) by cleavage of the bond between Lys157 and Ile158. After activation, Urokinase specifically cleaves the proenzyme plasminogen to form the active enzyme plasmin. The active plasmin then catalyzes the breakdown of fibrin polymers of blood clots. Urokinase is involved in a number of biological functions including fibrinolysis, embryogenesis, cell migration, tissue remodeling, ovulation, and wound healing. Additionally, it is a potent marker of invasion and metastasis in a variety of human cancers associated with breast, stomach, colon, bladder, ovary, brain and endometrium.


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