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Pro-MMP-8, human

A Protein involved in breakdown of extracellular matrix
Catalog #: 7784

Product Details

Cat # +Size 7784-5
Size 5 μg
Alternate Name Neutrophil collagenase (EC (Matrix metalloproteinase-8) (MMP-8) (PMNL collagenase) (PMNL-CL)
Gene Symbol MMP8
Gene ID 4317
Accession # P22894
Source Human neutrophil granulocytes (Buffy Coat)
Appearance Liquid
Physical Form Description In 50 mM Tris-HCl, pH 7; 200 mM NaCl; 5 mM CaCl₂; 1 μM ZnCl₂; 0.05% Brij 35; 0,05% NaN₃
Molecular Weight 40/42 kDa
Handling Centrifuge the vial prior to opening.
Storage Conditions -80°C
Shipping Conditions Dry Ice
USAGE For Research Use Only! Not to be used in humans


Human neutrophil collagenase (HNC) has been purified from extracts of fresh and outdated buffy coats and from exudates of phorbol myristate acetate-stimulated neutrophils. The MMP-8 present in the starting material can either be latent or active, or have an app. relative molecular mass of 75-kDa and/or 58-kDa. The rather complex pattern of activation of the latent 58-kDa and 75-kDa species by trypsin, organomercurials and oxidants has been investigated. MMP-8 was shown to preferentially hydrolyze type I over type II, and type III collagens in solution and to be a glycoprotein that contains complex N-linked oligosaccharides leading to multiple forms of MMP-8 in SDS-PAGE. The action of endoglycosidase on the latent 58-kDa form produces 42/40-kDa species (Gao et al. 1992, Mallya et al. 1990). This indicates that MMP-8 is an N-linked, complex glycoprotein that appears to be glycosylated at multiple sites.

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