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Pro-MMP-13, human recombinant

A Protein involved in breakdown of extracellular matrix
Catalog #: 7785
$345.00

Product Details

Cat # +Size 7785-10
Size 10 μg
Alternate Name Collagenase 3Collagenase 3 (EC 3.4.24.-) (Matrix metalloproteinase-13) (MMP-13)
Gene Symbol MMP13
Gene ID 4322
Accession # P45452
Source Sf9 cells
Appearance Liquid
Physical Form Description In 50 mM Tris pH 6.5, 250 mM NaCl, 5 mM CaCl2, 1 mM ZnCl2
Molecular Weight 53.820 kDa
Purity by SDS-PAGE ≥95%
Handling Centrifuge the vial prior to opening.
Storage Conditions -80°C
Shipping Conditions Dry Ice
USAGE For Research Use Only! Not to be used in humans

Details

MMP-13 (Collagenase-3) was first identified in human mammacarcinoma (Freije et al., 1994, Willmroth et al. 1998) - probably induced by IL1- alpha and IL-1 beta - and shown to be glycosylated and the inactive zymogen displaying a relative molecular weight of 60 kDa. Cleavage of the 84 residue propeptide can be catalysed by other MMPs such as MMP-2, MMP-3 and MMP-14, or by factors like plasmin. The proenzyme activated by APMA (paminohenylmercuric acteate) or leads to the active enzyme with a relative molecular weight of app. 48 kDa which easily autodegrades into a 30 kDa form. This highly active 30 kDa form still retains the characteristics of the app. 48 kDa form. MMP-13 also plays a central role in the MMP activation cascade, both activating and being activated by several MMPs (Leeman et al., 2002).


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