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PRMT4/CARM1 Inhibitor

An inhibitor of Protein Arginine Methyltransferase 4/Coactivator-Associated Arginine Methyltransferase 1
Catalog #: B2808
SKU-Size Size Price Qty
B2808-500 500 μg
B2808-1000 1000 μg
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Product Details

Alternate Name Protein Arginine Methyltransferase 4/Coactivator-Associated Arginine Methyltransferase 1 Inhibitor, (3E,5E)-1-benzyl-3,5-bis[(3-bromo-4-hydroxyphenyl)methylidene]piperidin-4-one, CARM1-IN-1
Appearance Crystalline solid
CAS # 1020399-49-8
Molecular Formula C₂₆H₂₁Br₂NO₃
Molecular Weight 555.26
Purity ≥95%
Solubility ~35 mg/ml in DMSO
InChi InChI=1S/C26H21Br2NO3/c27-22-12-18(6-8-24(22)30)10-20-15-29(14-17-4-2-1-3-5-17)16-21(26(20)32)11-19-7-9-25(31)23(28)13-19/h1-13,30-31H,14-16H2/b20-10+,21-11+
PubChem CID 24827559
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


PRMT4/CARM1 Inhibitor is highly selective in blocking the activity of Protein Arginine Methyltransferase 4/Coactivator-Associated Arginine Methyltransferase 1. The IC₅₀ value of inhibition is 7.1 µM. In human prostate adenocarcinoma cancer LNCaP cells, PRMT4/CARM1 inhibitor showed a significant dose-dependent reduction of the prostate-specific antigen promoter activity, at concentrations that did not affect cell viability.

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