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A low affinity dopamine D2 receptor antagonist and a potent sigma-1 receptor (S1R) agonist
Catalog #: B3045
SKU-Size Size Price Qty
B3045-5 5 mg
B3045-25 25 mg
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Product Details

Alternate Name 4-[3-(Methylsulfonyl)phenyl]-1-propylpiperidine; 4-(3-Methanesulfonyl-phenyl)-1-propyl-piperidine; ACR16; Huntexil
Appearance White Solid
CAS # 346688-38-8
Molecular Formula C₁₅H₂₃NO₂S
Molecular Weight 281.41
Purity ≥97%
Solubility Soluble in DMSO
InChi InChI=1S/C15H23NO2S/c1-3-9-16-10-7-13(8-11-16)14-5-4-6-15(12-14)19(2,17)18/h4-6,12-13H,3,7-11H2,1-2H3
PubChem CID 9795739
MDL Number MFCD09835586
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions RT
USAGE For Research Use Only! Not For Use in Humans.


Pridopidine is a phenylpiperidine dopaminergic stabilizer. It is a low affinity dopamine D2 receptor antagonist and a potent sigma-1 receptor (S1R) agonist. The affinity of pridopidine for S1R is 100-fold higher than the affinity for D2 Receptor (high-affinity Ki of 70 nM at S1R and 7520 nM at D2 receptor). It improves motor function and shows neuroprotective effects in Huntington Disease mouse model. Due to interaction of the SARS-CoV-2 proteins Nsp6 and Orf9c with sigma receptors, modulators of sigma receptors are being investigated for the treatment of SARS-Cov-2.

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