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Prexasertib mesylate

A checkpoint kinase 1 (chk1) inhibitor
Catalog #: B2067
SKU-Size Size Price Qty
B2067-5 5 mg
B2067-25 25 mg
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Product Details

Alternate Name 5-[[5-[2-(3-aminopropoxy)-6-methoxyphenyl]-1H-pyrazol-3-yl]amino]pyrazine-2-carbonitrile;methanesulfonic acid; LY-2606368; LY2606368
Appearance Yellow solid
CAS # 1234015-55-4
Molecular Formula C₁₉H₂₃N₇O₅S
Molecular Weight 461.5
Purity ≥98% by HPLC
Solubility DMSO
InChi InChI=1S/C18H19N7O2.CH4O3S/c1-26-14-4-2-5-15(27-7-3-6-19)18(14)13-8-16(25-24-13)23-17-11-21-12(9-20)10-22-17;1-5(2,3)4/h2,4-5,8,10-11H,3,6-7,19H2,1H3,(H2,22,23,24,25);1H3,(H,2,3,4)
PubChem CID 46837045
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


Prexasertib is a potent inhibitor of checkpoint kinase 1 (chk1) with potential antineoplastic activity. Upon administration, prexasertib selectively binds to chk1, thereby preventing activity of chk1 and abrogating the repair of damaged DNA. This may lead to an accumulation of damaged DNA and may promote genomic instability and apoptosis.

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