Product Details
| abID | ab286944 |
|---|---|
| Alternate Name | 2-morpholin-4-ylethyl 1-phenylcyclohexane-1-carboxylate;hydrochloride |
| Appearance | White to Off-White Solid |
| CAS # | 75136-54-8 |
| Molecular Formula | C₁₉H₂₈ClNO₃ |
| Molecular Weight | 353.88 |
| Purity | ≥98% |
| Solubility | ~1.1 mg/ml in DMSO and DMF |
| SMILES | C1CCC(CC1)(C2=CC=CC=C2)C(=O)OCCN3CCOCC3.Cl |
| InChi | InChI=1S/C19H27NO3.ClH/c21-18(23-16-13-20-11-14-22-15-12-20)19(9-5-2-6-10-19)17-7-3-1-4-8-17;/h1,3-4,7-8H,2,5-6,9-16H2;1H |
| InChi Key | QUJWFJNHTBKCLU-UHFFFAOYSA-N |
| PubChem CID | 11314197 |
| MDL Number | MFCD00153919 |
| Handling | Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure. |
| Storage Conditions | -20ºC |
| Shipping Conditions | RT |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
PRE-084 is a high affinity sigma receptor 1 (σ1) agonist. It shows Ki values of 2.2 and 13,091 nM for σ1 and σ2 receptors, respectively and an IC₅₀ of 44 nM in the sigma receptor assay. It does not show significant activity for PCP and other receptors (IC₅₀ > 10,000 nM). PRE-084 has beneficial effects in a cellular model of Huntington's disease. It (0.3 μM) decreases the deleterious effects of N-terminal mutant huntington proteins in neuronal PC6.3 cells by activating NF-κB pathway and decreasing oxidative stress. Modulators of sigma receptor 1 may be beneficial against SARS-CoV-2 based on interaction of sigma receptors with SARS-CoV-2 protein Nsp6.
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