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PRE-084 Hydrochloride

A high affinity sigma receptor 1 agonist
Catalog #: B3049
SKU-Size Size Price Qty
B3049-5 5 mg
$60.00
B3049-25 25 mg
$240.00
More Sizes Get Quote

Product Details

Alternate Name 2-morpholin-4-ylethyl 1-phenylcyclohexane-1-carboxylate;hydrochloride
Appearance White to Off-White Solid
CAS # 75136-54-8
Molecular Formula C₁₉H₂₈ClNO₃
Molecular Weight 353.88
Purity ≥98%
Solubility ~1.1 mg/ml in DMSO and DMF
SMILES C1CCC(CC1)(C2=CC=CC=C2)C(=O)OCCN3CCOCC3.Cl
InChi InChI=1S/C19H27NO3.ClH/c21-18(23-16-13-20-11-14-22-15-12-20)19(9-5-2-6-10-19)17-7-3-1-4-8-17;/h1,3-4,7-8H,2,5-6,9-16H2;1H
InChi Key QUJWFJNHTBKCLU-UHFFFAOYSA-N
PubChem CID 11314197
MDL Number MFCD00153919
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions RT
USAGE For Research Use Only! Not For Use in Humans.

Details

PRE-084 is a high affinity sigma receptor 1 (σ1) agonist. It shows Ki values of 2.2 and 13,091 nM for σ1 and σ2 receptors, respectively and an IC₅₀ of 44 nM in the sigma receptor assay. It does not show significant activity for PCP and other receptors (IC₅₀ > 10,000 nM). PRE-084 has beneficial effects in a cellular model of Huntington's disease. It (0.3 μM) decreases the deleterious effects of N-terminal mutant huntington proteins in neuronal PC6.3 cells by activating NF-κB pathway and decreasing oxidative stress. Modulators of sigma receptor 1 may be beneficial against SARS-CoV-2 based on interaction of sigma receptors with SARS-CoV-2 protein Nsp6.


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