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PPQ-102

A CFTR inhibitor
Catalog #: B3353
SKU-Size Size Price Qty
B3353-5 5 mg
$135.00
B3353-25 25 mg
$535.00
More Sizes Get Quote

Product Details

Alternate Name 6,7-dihydro-7,9-dimethyl-6-(5-methyl-2-furanyl)-11-phenyl-pyrimido[4',5':3,4]pyrrolo[1,2-a]quinoxaline-8,10(5H,9)-dione
Appearance Yellow solid
CAS # 931706-15-9
Molecular Formula C₂₆H₂₂N₄O₃
Molecular Weight 438.48
Purity ≥98% by HPLC
Solubility >5 mg/ml DMSO
SMILES CC1=CC=C(O1)C2C3=C4C(=C(N3C5=CC=CC=C5N2)C6=CC=CC=C6)C(=O)N(C(=O)N4C)C
InChi InChI=1S/C26H22N4O3/c1-15-13-14-19(33-15)21-24-23-20(25(31)29(3)26(32)28(23)2)22(16-9-5-4-6-10-16)30(24)18-12-8-7-11-17(18)27-21/h4-14,21,27H,1-3H3
InChi Key MNOOVRNGPIWJDI-UHFFFAOYSA-N
PubChem CID 16016583
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

PPQ -102 is a potent, voltage-independent CFTR chloride channel inhibitor (IC50 = 90 nM). PPQ-102 displays nephroprotective and anti-fibrotic activities, decreasing the size of pre-formed kidney cysts in animal models of polycystic kidney disease.


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