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PP121

A dual inhibitor of tyrosine and phosphoinositide kinases
Catalog #: B2523
SKU-Size Size Price Qty
B2523-5 5 mg
$85.00
B2523-25 25 mg
$335.00
More Sizes Get Quote

Product Details

Alternate Name 1-cyclopentyl-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)pyrazolo[3,4-d]pyrimidin-4-amine; PP-121
Peptide Sequence N/A
Appearance Crystalline solid
CAS # 1092788-83-4
Molecular Formula C₁₇H₁₇N₇
Molecular Weight 319.37
Purity ≥98% by HPLC
Solubility >20 mg/ml in DMSO
SMILES C1CCC(C1)N2C3=C(C(=N2)C4=CN=C5C(=C4)C=CN5)C(=NC=N3)N
InChi InChI=1S/C17H17N7/c18-15-13-14(11-7-10-5-6-19-16(10)20-8-11)23-24(12-3-1-2-4-12)17(13)22-9-21-15/h5-9,12H,1-4H2,(H,19,20)(H2,18,21,22)
InChi Key NVRXTLZYXZNATH-UHFFFAOYSA-N
PubChem CID 24905142
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

PP121 is a dual inhibitor of tyrosine and phosphoinositide kinases. PP121 inhibits both tyrosine kinases and PI3-Ks but not serine-threonine kinases. It potently inhibits p110α, p110β, p110γ, p110δ, DNA-PK and mTOR with IC50 values of 52nM, 1.4μM, 1.1μM, 150nM, 60nM and 10nM, respectively. For the tyrosine kinases, PP121 displays inhibition with IC50 values of 21nM, 4nM, 10nM,55nM, 550nM, 220nM and <1nM for Ab1, Hck, Src, VEGFR2, EGFR, EphB4 and PDGFR, respectively.


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