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Poziotinib

A an irreversible Pan-HER inhibitor
Catalog #: 9519
SKU-Size Size Price Qty
9519-10 10 mg
$125.00
9519-50 50 mg
$495.00
More Sizes Get Quote

Product Details

Alternate Name 1-(4-((4-((3,4-dichloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)piperidin-1-yl)prop-2-en-1-one; HM781-36B; NOV120101
Appearance White to off-white solid
CAS # 1092364-38-9
Molecular Formula C₂₃H₂₁Cl₂FN₄O₃
Molecular Weight 491.34
Purity ≥98% by HPLC
Solubility DMSO (>5 mg/ml)
SMILES COC1=C(C=C2C(=C1)N=CN=C2NC3=C(C(=C(C=C3)Cl)Cl)F)OC4CCN(CC4)C(=O)C=C
InChi InChI=1S/C23H21Cl2FN4O3/c1-3-20(31)30-8-6-13(7-9-30)33-19-10-14-17(11-18(19)32-2)27-12-28-23(14)29-16-5-4-15(24)21(25)22(16)26/h3-5,10-13H,1,6-9H2,2H3,(H,27,28,29)
InChi Key LPFWVDIFUFFKJU-UHFFFAOYSA-N
PubChem CID 25127713
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Poziotinib is an irreversible Pan-HER inhibitor with IC₅₀s of 3 nM, 5 nM and 23 nM for HER1, HER2, and HER4 respectively. Displays antineoplastic activity.


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