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Ponatinib

A potent multi-kinase and pan-BCR-Abl inhibitor.
Catalog #: 2712
SKU-Size Size Price Qty
2712-50 50 mg
$675.00
2712-10 10 mg
$165.00
More Sizes Get Quote

Product Details

Alternate Name 3-(2-Imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-benzamide; AP24534
Appearance White solid
CAS # 943319-70-8
Molecular Formula C₂₉H₂₇F₃N₆O
Molecular Weight 532.56
Purity ≥98% by HPLC
Solubility DMSO (~50 mg/ml) or EtOH (~ 25 mg/ml)
SMILES CC1=C(C=C(C=C1)C(=O)NC2=CC(=C(C=C2)CN3CCN(CC3)C)C(F)(F)F)C#CC4=CN=C5N4N=CC=C5
InChi InChI=1S/C29H27F3N6O/c1-20-5-6-22(16-21(20)8-10-25-18-33-27-4-3-11-34-38(25)27)28(39)35-24-9-7-23(26(17-24)29(30,31)32)19-37-14-12-36(2)13-15-37/h3-7,9,11,16-18H,12-15,19H2,1-2H3,(H,35,39)
InChi Key PHXJVRSECIGDHY-UHFFFAOYSA-N
PubChem CID 24826799
MDL Number MFCD17215203
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Ponatinib is a multi-targeted tyrosine kinase inhibitor that is active against T315I and other BCR-Abl mutants. It inhibits all tested BCR-Abl mutants in cellular and biochemical assays, suppresses BCR-Abl(T315I)-driven tumor growth in mice, and completely abrogates resistance in cell-based mutagenesis screens.


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