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Pomalidomide

A second-generation immunomodulatory drug
Catalog #: B1811

In stock

SKU-Size Size Price Qty
B1811-5 5 mg
$95.00
B1811-25 25 mg
$375.00

Product Details

Alternate Name 4-amino-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione; CC4047
Appearance Yellow solid
CAS # 19171-19-8
Molecular Formula C₁₃H₁₁N₃O₄
Molecular Weight 273.24
Purity ≥98%
Solubility DMSO (>8 mg/ml)
SMILES C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C(=CC=C3)N
InChi InChI=1S/C13H11N3O4/c14-7-3-1-2-6-10(7)13(20)16(12(6)19)8-4-5-9(17)15-11(8)18/h1-3,8H,4-5,14H2,(H,15,17,18)
InChi Key UVSMNLNDYGZFPF-UHFFFAOYSA-N
PubChem CID 134780
MDL Number MFCD12756407
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Pomalidomide is a derivative of Thalidomide (Cat. No. 2020) and a second-generation immunomodulatory drug. Pomalidomide targets the E3 ligase protein cereblon, preventing cereblon autoubiquitination activity. It has been shown to exert antiproliferative, antiangiogenic, and immunomodulatory effects against myeloma cells, modulating cell adhesion, decreasing production of key pro-survival cytokines, including TNF-α.


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