Poly(I:C)

A double-stranded homopolymer and Toll-like receptor 3 (TLR3) agonist
Catalog #: B2989 | abID:

Product Details

Alternate Name [(2R,3S,4R,5R)-5-(4-amino-2-oxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl dihydrogen phosphate--[(2R,3S,4R,5R)-3,4-dihydroxy-5-(6-oxo-1H-purin-9-yl)oxolan-2-yl]methyl dihydrogen phosphate; Polyinosinic acid-polycytidylic acid; Poly I:poly C; Polyinosinic acid, homopolymer, complex with polycytidylic acid, homopolymer (1:1)
Appearance White to off-white powder
CAS # 24939-03-5
Molecular Formula (C₁₀H₁₃N₄O₈P)x·(C₉H₁₄N₃O₈P)x
Molecular Weight 671.4
Purity >95%
Solubility To prevent denaturation, this product should be reconstituted in solutions with physiological salt concentrations. Ultrasonication or gentle warming can be carried out for improving solubility. ~3 mg/ml in Water
SMILES C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC2=C(C(=O)N1)N=CN2C3C(C(C(O3)COP(=O)(O)O)O)O
InChi InChI=1S/C10H13N4O8P.C9H14N3O8P/c15-6-4(1-21-23(18,19)20)22-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17;10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h2-4,6-7,10,15-16H,1H2,(H,11,12,17)(H2,18,19,20);1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/t4-,6-,7-,10-;4-,6-,7-,8-/m11/s1
InChi Key ACEVNMQDUCOKHT-ZLOOHWKQSA-N
PubChem CID 135618150
MDL Number MFCD00131957
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Poly(I:C) is a double-stranded homopolymer of polyinosinic acid and polycytidylic acid. Transfection of Poly(I:C) (1 μg/ml) into NIT 1 cells has been used as a model of intracellular double-stranded RNA-induced beta-cell apoptosis. Poly(I:C) induced apoptosis in 45% of the cells, 18h after transfection. Maturation mixtures containing various cytokines, IFN-γ and TLR3 agonist poly(I:C) in combination with TLR7/8 agonists R848 or CL075 yield 3-d mature dendritic cells that secrete high levels of IL-12(p70) and show strong chemotaxis to CCR7 ligands. Epigenetic modulation of cardiac progenitor cells with Poly(I:C) accelerates maturation of cardiomyocytes.


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