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PNU-74654

A β-catenin inhibitor
Catalog #: B1837
SKU-Size Size Price Qty
B1837-5 5 mg
$125.00
B1837-25 25 mg
$495.00
More Sizes Get Quote

Product Details

Alternate Name 2-Phenoxybenzoic acid-[(5-methyl-2-furanyl)methylene]hydra-zide
Appearance White solid
CAS # 113906-27-7
Molecular Formula C₁₉H₁₆N₂O₃
Molecular Weight 320.34
Purity ≥98% by HPLC
Solubility DMSO (>30 mg/ml)
SMILES CC1=CC=C(O1)C=NNC(=O)C2=CC=CC=C2OC3=CC=CC=C3
InChi InChI=1S/C19H16N2O3/c1-14-11-12-16(23-14)13-20-21-19(22)17-9-5-6-10-18(17)24-15-7-3-2-4-8-15/h2-13H,1H3,(H,21,22)
InChi Key JJEDWBQZCRESJL-UHFFFAOYSA-N
PubChem CID 60119583
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

PNU-74654 is a β-catenin inhibitor (Kd = 450 nM), inhibiting its interaction with the transcription factor T cell factor 4 (Tcf4) resulting in disruption of the Wnt signaling pathway. Treatment of human adrenocortical cell lines with PNU-74654 significantly reduces expression of several Tcf/β-catenin target genes.


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