Product Details
| Alternate Name | 2-Phenoxybenzoic acid-[(5-methyl-2-furanyl)methylene]hydra-zide |
|---|---|
| Appearance | White solid |
| CAS # | 113906-27-7 |
| Molecular Formula | C₁₉H₁₆N₂O₃ |
| Molecular Weight | 320.34 |
| Purity | ≥98% by HPLC |
| Solubility | DMSO (>30 mg/ml) |
| SMILES | CC1=CC=C(O1)C=NNC(=O)C2=CC=CC=C2OC3=CC=CC=C3 |
| InChi | InChI=1S/C19H16N2O3/c1-14-11-12-16(23-14)13-20-21-19(22)17-9-5-6-10-18(17)24-15-7-3-2-4-8-15/h2-13H,1H3,(H,21,22) |
| InChi Key | JJEDWBQZCRESJL-UHFFFAOYSA-N |
| PubChem CID | 60119583 |
| Handling | Protect from air and light |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
PNU-74654 is a β-catenin inhibitor (Kd = 450 nM), inhibiting its interaction with the transcription factor T cell factor 4 (Tcf4) resulting in disruption of the Wnt signaling pathway. Treatment of human adrenocortical cell lines with PNU-74654 significantly reduces expression of several Tcf/β-catenin target genes.
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