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PND-1186

A potent FAK (Focal adhesion kinase) inhibitor
Catalog #: 2823
SKU-Size Size Price Qty
2823-5 5 mg
$125.00
2823-25 25 mg
$495.00
More Sizes Get Quote

Product Details

Alternate Name 2-((2-((2-methoxy-4-morpholinophenyl)amino)-5-(trifluoromethyl)pyridin-4-yl)amino)-N-methylbenzamide; VS-4718; SR-2516;PND 1186;PND1186;SR 2516;SR2516
Appearance White to off-white solid
CAS # 1061353-68-1
Molecular Formula C₂₅H₂₆F₃N₅O₃
Molecular Weight 501.5
Purity ≥98% by HPLC
Solubility DMSO
SMILES CNC(=O)C1=CC=CC=C1NC2=CC(=NC=C2C(F)(F)F)NC3=C(C=C(C=C3)N4CCOCC4)OC
InChi InChI=1S/C25H26F3N5O3/c1-29-24(34)17-5-3-4-6-19(17)31-21-14-23(30-15-18(21)25(26,27)28)32-20-8-7-16(13-22(20)35-2)33-9-11-36-12-10-33/h3-8,13-15H,9-12H2,1-2H3,(H,29,34)(H2,30,31,32)
InChi Key IGUBBWJDMLCRIK-UHFFFAOYSA-N
PubChem CID 25073775
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

PND-1186 is a potent FAK (Focal adhesion kinase) inhibitor (IC₅₀ = 1.5 nM) with potential antineoplastic activity. PND-1186 inhibits FAK, blocks fibronectin-stimulated FAK autophosphorylation of Tyr397, and may prevent the integrin-mediated activation of several downstream signal transduction pathways, including ERK, JNK/MAPK and PI3K/Akt. This results in the reduction of the number of cancer stem cells (CSCs) and inhibits tumor cell migration, proliferation and survival.


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