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PLX5622 (free base)

An inhibitor of CSF1R
Catalog #: B2965
SKU-Size Size Price Qty
B2965-5 5 mg
B2965-25 25 mg
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Product Details

Alternate Name 6-fluoro-N-[(5-fluoro-2-methoxypyridin-3-yl)methyl]-5-[(5-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl]pyridin-2-amine
Appearance Solid
CAS # 1303420-67-8
Molecular Formula C₂₁H₁₉F₂N₅O
Molecular Weight 395.41
Purity >98%
Solubility Soluble in DMSO
InChi InChI=1S/C21H19F2N5O/c1-12-5-17-14(9-26-20(17)25-8-12)6-13-3-4-18(28-19(13)23)24-10-15-7-16(22)11-27-21(15)29-2/h3-5,7-9,11H,6,10H2,1-2H3,(H,24,28)(H,25,26)
PubChem CID 52936034
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions RT
USAGE For Research Use Only! Not For Use in Humans.


PLX5622 is an inhibitor of colony-stimulating factor 1 receptor (CSF1R) tyrosine kinase with a Ki of 5.9 nM. It causes sustained and specific elimination of microglia. As a result of microglial depletion, plaques fail to form in the parenchymal space in the 5xFAD mouse model of Alzheimer’s disease (AD). Inhibition of the CSF1R at lower doses in 3xTg-AD mice prevents microglial association with plaques and improves cognition.

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