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PLX-8394

A potent B-raf (BRAF) inhibitor
Catalog #: B2428

In stock

SKU-Size Size Price Qty
B2428-5 5 mg
$115.00
B2428-25 25 mg
$455.00
More Sizes Get Quote

Product Details

Alternate Name (R)-N-(3-(5-(2-cyclopropylpyrimidin-5-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)-3-fluoropyrrolidine-1-sulfonamide, PLX8394
Appearance Off-white solid
CAS # 1393466-87-9
Molecular Formula C₂₅H₂₁F₃N₆O₃S
Molecular Weight 542.54
Purity ≥98% by HPLC
Solubility in DMSO
SMILES C1CC1C2=NC=C(C=N2)C3=CN=C4C(=C3)C(=CN4)C(=O)C5=C(C=CC(=C5F)NS(=O)(=O)N6CCC(C6)F)F
InChi InChI=1S/C25H21F3N6O3S/c26-16-5-6-34(12-16)38(36,37)33-20-4-3-19(27)21(22(20)28)23(35) 18-11-32-25-17(18) 7-14(8-31-25)15-9-29-24(30-10-15)13-1-2-13/h3-4,7-11,13,16,33H,1-2,5-6, 12H2,(H,31,32)/t16-/m1/s1
InChi Key YYACLQUDUDXAPA-MRXNPFEDSA-N
PubChem CID 90116675
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

PLX-8394 is a potent inhibitor of serine/threonine-protein kinase B-raf (BRAF) protein with potential antineoplastic activity. PLX-8394 selectively binds to and inhibits the activity of both wild-type and mutated forms of BRAF, which may subsequently inhibit the proliferation of tumor cells which express mutated forms of BRAF.


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