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PLX-51107

A potent and selective BRD4 inhibitor
Catalog #: B2511
SKU-Size Size Price Qty
B2511-1 1 mg
$85.00
B2511-5 5 mg
$295.00
More Sizes Get Quote

Product Details

Alternate Name (S)-4-(6-(3,5-dimethylisoxazol-4-yl)-1-(1-(pyridin-2-yl)ethyl)-1H-pyrrolo[3,2-b]pyridin-3-yl)benzoic acid
PLX51107
Appearance White to off-white solid
CAS # 1627929-55-8
Molecular Formula C₂₆H₂₂N₄O₃
Molecular Weight 438.49
Purity ≥98% by HPLC
Solubility >50 mg/ml in DMSO
SMILES CC1=C(C(=NO1)C)C2=CC3=C(C(=CN3C(C)C4=CC=CC=N4)C5=CC=C(C=C5)C(=O)O)N=C2
InChi InChI=1S/C26H22N4O3/c1-15-24(17(3)33-29-15)20-12-23-25(28-13-20)21(18-7-9-19(10-8-18)26(31)32)14-30(23)16(2)22-6-4-5-11-27-22/h4-14, 16H,1-3H3,(H,31,32)/t16-/m0/s1
InChi Key AMSUHYUVOVCWTP-INIZCTEOSA-N
PubChem CID 90448953
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

PLX-51107 is a potent inhibitor of the bromodomain-containing protein 4 (BRD4), with potential antineoplastic activity. Upon administration, PLX51107 binds to the acetylated lysine recognition motifs in the bromodomains of the BRD4 protein, thereby preventing the binding of BRD4 to acetylated lysines on histones. This disrupts chromatin remodeling and gene expression.


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