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A potent, ATP-competitive B-raf inhibitor
Catalog #: 2813
SKU-Size Size Price Qty
2813-5 5 mg
2813-25 25 mg
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Product Details

Alternate Name N-[3-(5-chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl]propane-1-sulfonamide
Appearance White solid
CAS # 918505-84-7
Molecular Formula C₁₇H₁₄ClF₂N₃O₃S
Molecular Weight 413.83
Purity ≥98% by HPLC
Solubility DMSO (>80 mg/ml)
InChi InChI=1S/C17H14ClF2N3O3S/c1-2-5-27(25,26)23-13-4-3-12(19)14(15(13)20)16(24)11-8-22-17-10(11)6-9(18)7-21-17/h3-4,6-8,23H,2,5H2,1H3,(H,21,22)
PubChem CID 24180719
MDL Number MFCD14635203
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


PLX-4720 is a potent, ATP-competitive B-raf inhibitor (IC₅₀ =160 nM). PLX-4720 preferentially inhibits the active B-Raf(V600E) kinase compared with a broad spectrum of other kinases, and potent cytotoxic effects are also exclusive to cells bearing the V600E allele.

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