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Pluripotin

A regulator of mouse embryonic stem cell (ESC) self-renewal
Catalog #: 2165
SKU-Size Size Price Qty
2165-1 1 mg
$145.00
2165-5 5 mg
$565.00
More Sizes Get Quote

Product Details

Alternate Name N-​(3-​(7-​(1,​3-​dimethyl-​1H-​pyrazol-​5-​ylamino)-​1-​methyl-​2-​oxo- ​1,​2-​dihydropyrimido[4,​5-​d]pyrimidin-​3(4H)-​yl)-​4-​methylphenyl)-​ 3-​(trifluoromethyl)benzamide; SC1
Appearance White solid
CAS # 839707-37-8
Molecular Formula C₂₇H₂₅F₃N₈O₂
Molecular Weight 550.54
Purity ≥97% by HPLC
Solubility DMSO (100 mM)
SMILES CC1=C(C=C(C=C1)NC(=O)C2=CC(=CC=C2)C(F)(F)F)N3CC4=CN=C(N=C4N(C3=O)C)NC5=CC(=NN5C)C
InChi InChI=1S/C27H25F3N8O2/c1-15-8-9-20(32-24(39)17-6-5-7-19(11-17)27(28,29)30)12-21(15)38-14-18-13-31-25(34-23(18)36(3)26(38)40)33-22-10-16(2)35-37(22)4/h5-13H,14H2,1-4H3,(H,32,39)(H,31,33,34)
InChi Key NBZFRTJWEIHFPF-UHFFFAOYSA-N
PubChem CID 12003241
MDL Number MFCD20527253
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Pluripotin (SC1) regulates mouse embryonic stem cell (ESC) self-renewal. It was shown that SC1 is sufficient for sustaining long-term self-renewal of mouse ES cells in an undifferentiated state in the absence of LIF, feeder cells, or serum. SC1 acts through dual inhibition of Ras-GAP and ERK1 with Kd values of 98 and 212 nM, respectively.


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