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Product Details
| Alternate Name | 5-Hydroxy-2-methyl-1,4-naphthalenedione |
|---|---|
| Peptide Sequence | No |
| Appearance | Orange red solid |
| CAS # | 481-42-5 |
| Molecular Formula | C₁₁H₈O₃ |
| Molecular Weight | 188.18 |
| Purity | ≥98% |
| Solubility | DMSO (~20 mg/ml) or EtOH (~10 mg/ml) |
| SMILES | CC1=CC(=O)C2=C(C1=O)C=CC=C2O |
| InChi | InChI=1S/C11H8O3/c1-6-5-9(13)10-7(11(6)14)3-2-4-8(10)12/h2-5,12H,1H3 |
| InChi Key | VCMMXZQDRFWYSE-UHFFFAOYSA-N |
| PubChem CID | 10205 |
| MDL Number | MFCD00001682 |
| Handling | Protect from air and light |
| Storage Conditions | -20 ̊C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
A quinonoid constituent isolated from the root of Plumbago zeylanica. Displays anticarcinogenic, antiatherosclerotic, and antimicrobial effects as well as anticancer and antiproliferation properties in a variety of cell lines and animal models. Induces G2/M and autophagy in breast cancer cells by inhibiting Akt/mTOR pathway. Also potently inhibits histone acetyltransferase (HAT) activity in vivo. Plumbagin specifically inhibits p300-mediated acetylation of p53 but not the acetylation by p300/CREB-binding protein associated factor, PCAF, in vivo.
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