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Plasminogen, Human Plasma

The inactive precursor of plasmin
Catalog #: 7549
$215.00

Product Details

Cat # +Size 7549-1
Size 1 mg
Alternate Name PLG
Gene Symbol PLG
Gene ID 5340
Accession # P00747
Source Human Plasma
Appearance Lyophilized
Physical Form Description Lyophilized from 20 mM Tris-HCl, pH 7.5, with 2 mM EDTA.
Molecular Weight 90.0 – 92.0 kDa
Purity by SDS-PAGE ≥95%
Reconstitution Instructions Following steps are necessary for complete recovery of the product. Centrifuge the vial prior to opening, add de-ionized H2O, gently swirl or vortex until the product is completely homogenized. To further dilute the product, use lyophilization buffer. Volume of de-ionized H2O is lot-specific.
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans

Details

Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. Plasminogen is the inactive precursor of plasmin. Plasminogen is activated by the action of either tissue plasminogen activator (tPA), which primarily activates the fibrinolytic (thrombolytic) activity of plasmin, or urokinase plasminogen activator (uPA), which is associated with extracellular matrix remodeling and cell migration. Plasmin cleaves fibrin/fibrinogen and blood coagulation factors V/Va and VIII/VIIIa. It activates matrix metalloproteinases by cleaving the inactive proenzymes. It is also involved in the activation of some growth factors, such as vascular endothelial growth factor (VEGF) and transforming growth factor β (TGF-β).


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