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A protein kinase inhibitor
Catalog #: 2052
SKU-Size Size Price Qty
2052-1 1 mg
2052-5 5 mg
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Product Details

Alternate Name 4'-N-Benzoyl Staurosporine; CGP-41251; Midostaurin
Appearance White solid
CAS # 120685-11-2
Molecular Formula C₃₅H₃₀N₄O₄
Molecular Weight 570.64
Purity ≥99% by HPLC
Solubility DMSO (~ 10 mg/ml)
InChi InChI=1S/C35H30N4O4/c1-35-32(42-3)25(37(2)34(41)19-11-5-4-6-12-19)17-26(43-35)38-23-15-9-7-13-20(23)28-29-22(18-36-33(29)40)27-21-14-8-10-16-24(21)39(35)31(27)30(28)38/h4-16,25-26,32H,17-18H2,1-3H3,(H,36,40)/t25-,26-,32-,35+/m1/s1
PubChem CID 9829523
MDL Number MFCD10687105
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


Cell-permeable. A derivative of Staurosporine (Cat. No. 1048) that inhibits a variety of serine/threonine and tyrosine kinases including protein kinase C (PKC) IC₅₀ = 50 nM), cyclic AMP-dependent protein kinase (PKA) (IC₅₀ = 2.4 µM), S6 kinase (IC₅₀ = 5.0 µM), and EGFR (IC₅₀ = 3.0 µM). PKC412 reverses the efflux function of the multidrug resistance (MDR)-1 gene product, P-glycoprotein (P-gp).

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