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Product Details
| Alternate Name | N-(6-Oxo-5,6-dihydro-phenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride |
|---|---|
| Appearance | Pale yellow solid |
| CAS # | 344458-15-7 |
| Molecular Formula | C₁₇H₁₇N₃O₂.HCl |
| Molecular Weight | 331.8 |
| Purity | ≥98% by HPLC |
| Solubility | DMSO (~30 mg/ml) or H₂O (~ 30 mg/ml) |
| SMILES | CN(C)CC(=O)NC1=CC2=C(C=C1)NC(=O)C3=CC=CC=C32.O.Cl |
| InChi | InChI=1S/C17H17N3O2.ClH.H2O/c1-20(2)10-16(21)18-11-7-8-15-14(9-11)12-5-3-4-6-13(12)17(22)19-15;;/h3-9H,10H2,1-2H3,(H,18,21)(H,19,22);1H;1H2 |
| InChi Key | YCALIZUKAFUQCH-UHFFFAOYSA-N |
| PubChem CID | 16219859 |
| MDL Number | MFCD03452993 |
| Handling | Protect from air and moisture |
| Storage Conditions | -20 ̊C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
A potent, water-soluble poly(ADP-ribose) polymerase (PARP) inhibitor (EC₅₀ = 20 nM). Inhibits peroxynitrite-induced cell necrosis and displays significant, dose-dependent anti-inflammatory effects in a variety of local inflammation models. Provides cardioprotection by decreasing myocardial infarct size. Suppresses cell growth in liver cancer cells.
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