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Pirfenidone

An antifibrotic agent
Catalog #: B2660
SKU-Size Size Price Qty
B2660-10 10 mg
$75.00
B2660-50 50 mg
$275.00
More Sizes Get Quote

Product Details

Alternate Name AMR 69; 5-methyl-1-phenyl-2(1H)-pyridinone
Appearance Off-white solid
CAS # 53179-13-8
Molecular Formula C₁₂H₁₁NO
Molecular Weight 185.23
Purity ≥98%
Solubility >15 mg/ml DMSO
SMILES CC1=CN(C(=O)C=C1)C2=CC=CC=C2
InChi InChI=1S/C12H11NO/c1-10-7-8-12(14)13(9-10)11-5-3-2-4-6-11/h2-9H,1H3
InChi Key ISWRGOKTTBVCFA-UHFFFAOYSA-N
PubChem CID 40632
MDL Number MFCD00866047
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Pirfenidone is a small molecule antifibrotic agent. Pirfenidone (300 mg/kg per day) inhibits fibrosis and inhibits increases in collagen content, fibrocyte pool size, and the levels of chemokines CCL2 and CCL12 in lung in a mouse model of pulmonary fibrosis induced by bleomycin. In a mouse model of non-alcoholic steatohepatitis (NASH), pirfenidone inhibits fibrosis and increases in hepatocyte apoptosis, lobular inflammation, and hepatic expression of the fibrosis-related genes Col1a1, Timp1, Tgfb1, Pdgfb, and Fgf2 when administered at a dose of 280 mg/kg but has no effect on steatosis. Pirfenidone also displays anti-inflammatory and antioxidant properties.


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