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An inhibitor of p53-mediated apoptosis
Catalog #: B1083
SKU-Size Size Price Qty
B1083-5 5 mg
B1083-25 25 mg
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Product Details

Alternate Name 2-phenylethyne-1-sulfonamide
Appearance White Solid
CAS # 64984-31-2
Molecular Formula C₈H₇NO₂S
Molecular Weight 181.21
Purity ≥98% by HPLC
Solubility DMSO (>15 mg/ml)
InChi InChI=1S/C8H7NO2S/c9-12(10,11)7-6-8-4-2-1-3-5-8/h1-5H,(H2,9,10,11)
PubChem CID 327653
MDL Number MFCD00181531
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


Pifithrin-μ (PFT-μ) is an inhibitor of p53-mediated apoptosis, preventing p53 binding to Bcl-xL and Bcl-2 at the mitochondria without affecting p53 transactivational activities. In vitro, PFT-μ binds both p53 (Kd = 0.82 mM) and Bcl-xL (Kd = 0.80 mM). It reduces p53-mediated apoptosis induced by γ-radiation in mouse thymocytes in vitro and protects mice from doses of radiation that cause lethal hematopoietic syndrome. At 25 μM, PFT-μ reduces apoptosis triggered by nutlin-3, which inhibits MDM2/p53 binding and potentiates p53-mediated growth arrest and apoptosis.

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