Call 408.493.1800 | Fax 408.493.1801 | Toll Free 800.891.9699 (US Only) | Email: [email protected]

Pifithrin-µ

An inhibitor of p53-mediated apoptosis
Catalog #: B1083
SKU-Size Size Price Qty
B1083-5 5 mg
$75.00
B1083-25 25 mg
$295.00
More Sizes Get Quote

Product Details

Alternate Name 2-phenylethyne-1-sulfonamide
Appearance White Solid
CAS # 64984-31-2
Molecular Formula C₈H₇NO₂S
Molecular Weight 181.21
Purity ≥98% by HPLC
Solubility DMSO (>15 mg/ml)
SMILES C1=CC=C(C=C1)C#CS(=O)(=O)N
InChi InChI=1S/C8H7NO2S/c9-12(10,11)7-6-8-4-2-1-3-5-8/h1-5H,(H2,9,10,11)
InChi Key ZZUZYEMRHCMVTB-UHFFFAOYSA-N
PubChem CID 327653
MDL Number MFCD00181531
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Pifithrin-μ (PFT-μ) is an inhibitor of p53-mediated apoptosis, preventing p53 binding to Bcl-xL and Bcl-2 at the mitochondria without affecting p53 transactivational activities. In vitro, PFT-μ binds both p53 (Kd = 0.82 mM) and Bcl-xL (Kd = 0.80 mM). It reduces p53-mediated apoptosis induced by γ-radiation in mouse thymocytes in vitro and protects mice from doses of radiation that cause lethal hematopoietic syndrome. At 25 μM, PFT-μ reduces apoptosis triggered by nutlin-3, which inhibits MDM2/p53 binding and potentiates p53-mediated growth arrest and apoptosis.


Why buy BioVision Products?
Innovation
Affordability
Global Presence
Technical Support
BioVision aims to provide our customers innovative tools for accelerating drug discovery and biological research. BioVision offers >8,000 products including the most comprehensive array of assay kits for key targets in Metabolic pathways.
BioVision is committed to providing the highest quality products at a competitive price.
We have a broad network of global distributors who are ready to address your research needs and ensure fast delivery.
Our highly trained Technical Support team provides comprehensive product support and is dedicated to resolving your issues quickly and efficiently.