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Product Details
| Cat # +Size | K461-100 |
|---|---|
| Size | 100 assays |
| Kit Summary | • Detection method- Fluorescence (RFU: 535/587 nm) • Species reactivity- Eukaryotes • Applications- This Kit provides a simple, highly sensitive in vitro assay for detecting Methylglyoxal levels in biological samples. |
| Detection Method | Fluorescence (Ex/Em 535/587nm) |
| Species Reactivity | Eukaryotes |
| Applications | This Kit provides a simple, highly sensitive in vitro assay for detecting Methylglyoxal levels in biological samples. |
| Features & Benefits | This Kit provides a simple, highly sensitive in vitro assay for detecting Methylglyoxal levels in biological samples. |
| Kit Components | • MG Assay Buffer • PicoProbe™ (in DMSO) • Substrate Mix A • Substrate Mix B • Enzyme Mix A • Enzyme Mix B • Enzyme Mix C • Extraction Solution • MG Standard (20 mM) |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
Methylglyoxal (MG, 2-oxopropanal, pyruvic aldehyde), a by-product of glycolysis, is a highly toxic, reactive dicarbonyl compound. It causes non-enzymatic glycation of proteins which yields irreversible advanced glycation end products (AGEs), leading to cross-linking or degradation of proteins. MG is associated with several pathologies including diabetes, aging and neurodegenerative diseases. Furthermore, recent studies have suggested that MG may induce carbonyl stress-type schizophrenia. BioVision’s PicoProbe™ Methylglyoxal Assay Kit (Fluorometric) can detect MG using an enzyme-coupled reaction which reduces the fluorogenic probe. The reduced fluorophore produces a stable signal (Ex/Em= 535/587nm), which is directly proportional to the amount of MG in samples. The assay is simple, reproducible and can specifically detect as low as 6 pmol of MG in a 100 µl reaction.
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