PicoProbe™ Methylglyoxal Assay Kit (Fluorometric)

First fluorometric kit in the market that can detect Methylglyoxal in samples

WARNING: This product can expose you to chemicals including Trichloroacetic Acid, which is [are] known to the State of California to cause cancer.  For more information go to www.P65Warnings.ca.gov.
Catalog #: K461 | abID: ab273284

Product Details

abID ab273284
Cat # +Size K461-100
Size 100 assays
Kit Summary • Detection method- Fluorescence (RFU: 535/587 nm)
• Species reactivity- Eukaryotes
• Applications- This Kit provides a simple, highly sensitive in vitro assay for detecting Methylglyoxal levels in biological samples.
Detection Method Fluorescence (Ex/Em 535/587nm)
Species Reactivity Eukaryotes
Applications This Kit provides a simple, highly sensitive in vitro assay for detecting Methylglyoxal levels in biological samples.
Features & Benefits This Kit provides a simple, highly sensitive in vitro assay for detecting Methylglyoxal levels in biological samples.
Kit Components • MG Assay Buffer
• PicoProbe™ (in DMSO)
• Substrate Mix A
• Substrate Mix B
• Enzyme Mix A
• Enzyme Mix B
• Enzyme Mix C
• Extraction Solution
• MG Standard (20 mM)
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Methylglyoxal (MG, 2-oxopropanal, pyruvic aldehyde), a by-product of glycolysis, is a highly toxic, reactive dicarbonyl compound. It causes non-enzymatic glycation of proteins which yields irreversible advanced glycation end products (AGEs), leading to cross-linking or degradation of proteins. MG is associated with several pathologies including diabetes, aging and neurodegenerative diseases. Furthermore, recent studies have suggested that MG may induce carbonyl stress-type schizophrenia. BioVision’s PicoProbe™ Methylglyoxal Assay Kit (Fluorometric) can detect MG using an enzyme-coupled reaction which reduces the fluorogenic probe. The reduced fluorophore produces a stable signal (Ex/Em= 535/587nm), which is directly proportional to the amount of MG in samples. The assay is simple, reproducible and can specifically detect as low as 6 pmol of MG in a 100 µl reaction.


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