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PicoProbe™ Glutamate Carboxypeptidase II Activity Assay Kit

Sensitive assay for the detection and quantification of active Glutamate Carboxypeptidase
Catalog #: K738

Product Details

Cat # +Size K738-100
Size 100 assays
Kit Summary Glutamate Carboxypeptidase II Activity Assay Kit: Convenient assay to measure GCPII activity in biological samples. Detection Limit: 0.5 µU.
Detection Method Fluorometric (Ex/Em= 535/587 nm)
Species Reactivity All
Applications Measurement of Glutamate Carboxypeptidase II Activity in Biological Samples/Preparations.
Features & Benefits • Sensitive assay for measuring GCPII activity in various biological samples
• HTS adaptable
• Simple procedure
• Fast and convenient
Kit Components • GCPII Assay Buffer
• PicoProbeTM (in DMSO)
• GCPII Positive Control
• Glutamate Standard (0.1 M)
• GCPII Substrate
• GCPII Developer
• GCPII Enzyme Mix
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


Glutamate Carboxypeptidase II [GCPII, EC; N-acetylated-alpha-linked acidic dipeptidase (NAALADase), prostate-specific membrane antigen (PSMA) or folate hydrolase (FOLH1)] is a zinc-metallopeptidase, multifunctional protein. In humans, it is mainly expressed in the nervous system, prostate, small intestine and kidney. In males, PSMA is overexpressed in patients suffering prostate cancer and thus, it is used as a diagnostic marker for this disease. NAALADase, the brain isozyme, plays an important role in Glutamate biosynthesis and could be used for treating neuronal damage caused by excess glutamate in brain. BioVision’s PicoProbe™ Glutamate Carboxypeptidase II Activity Assay Kit is a simple plate-based fluorometric assay for the measurement of GCPII activity in Biological Samples. The provided substrate is transaminated in the presence of GCPII producing glutamate. The detection system is based on an enzymatic reaction in which a fluorogenic probe is reduced generating a stable signal. The reduced fluorophore produces a strong signal which is directly proportional to the amount of active GCPII in samples. The assay can detect as low as 0.5 µU of Glutamate Carboxypeptidase II.

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