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PicoProbe™ Fructose-1,6-Bisphosphatase Inhibitor Screening Kit (F)

Simple assay for high-throughput screening of FBP1 inhibitors/activators
Catalog #: K399
$495.00

Product Details

Cat # +Size K399-100
Size 100 assays
Kit Summary • Detection method- Fluorescence (Ex/Em= 535/587 nm)
• Application-Screening/characterizing/studying DHFR inhibitors/activators
Detection Method (Ex/Em= 535/587 nm)
Species Reactivity Human
Applications Screening/characterizing/studying FBP1 inhibitors/activators
Features & Benefits • Simple and reliable test to screen FBP1 inhibitors/activators
• High-throughput compatible
• Includes Inhibitor Control (AMP)
Kit Components • FBP1 Assay Buffer
• FBP1 Substrate
• Human FBP1
• FBP1 Converter 1
• FBP1 Converter 2
• FBP1 Developer
• PicoProbeTM
• AMP (Inhibitor)
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Fructose-1,6-bispohphatase (FBP1) is responsible for the conversion of fructose-1,6-bisphosphate to fructose-6-phosphate in the rate determining step of gluconeogenesis. FBP1 is a tetramer that plays a role in regulating adiposity and appetite. FBP1 has emerged as an important therapeutic target to treat diabetes type 2 to regulate glucose levels during gluconeogenesis. In BioVision’s FBP1 Inhibitor Screening Kit, human FBP1 hydrolyzes fructose-1,6-bisphosphate to fructose-6-phosphate which oxidizes and reacts with a fluorogenic probe, that is detected at Ex/Em= 535/587 nm. The assay is fast, sensitive, high-throughput compatible and provides a quick and sensitive way for screening, studying and characterizing potential novel inhibitors of FBP1


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