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PI3K (p85⍺) Protein

Intracellular signal transducer enzyme
Catalog #: 7766
SKU-Size Size Price Qty
7766-5 5 μg
$295.00
7766-100 100 μg
$3,950.00
More Sizes Get Quote

Product Details

Alternate Name PI3K (p85⍺) Protein, PI3K, PI3 kinase
Gene Symbol PIK3R1
Gene ID 5295
Accession # NM_181523
Source Baculovirus (Sf9 insect cells)
Appearance Liquid
Physical Form Description Recombinant protein in storage buffer (50 mM sodium phosphate, pH 7.0, 300 mM NaCl, 2 mM DTT, 150 mM imidazole, 0.1 mM PMSF, 25 % glycerol.).
Molecular Weight 86.0 kDa
Purity by SDS-PAGE ≥95%
Handling Centrifuge the vial prior to opening.
Storage Conditions -80°C
Shipping Conditions Dry Ice
USAGE For Research Use Only! Not to be used in humans

Details

The PI3K comprises of a 110 kDa catalytic subunit and a 85 kDa regulatory subunit. A number of isoforms of the 110 kDa catalytic subunit and the 85 kDa regulatory subunit exist in cells. p85αmodulates the interaction between PI3K and platelet-derived growth factor receptor (1). Furthermore, estrogen receptor isoform ER-alpha binds in a ligand-dependent manner to the p85α regulatory subunit of PI3K. Stimulation with estrogen increases ER-alpha-associated PI3K activity, leading to the activation of protein kinase B/AKT and endothelial nitric oxide synthase (eNOS) (2).


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