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PI-103

based on 1 citations in multiple journalsPI-10314.1 4
A PI3 Kinase inhibitor
Catalog #: 1728

In stock

SKU-Size Size Price Qty
1728-1 1 mg
$95.00
1728-5 5 mg
$340.00
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Product Details

Alternate Name 3-(4-(4-Morpholinyl)pyrido[3′,2′:4,5]furo[3,2-d]pyrimidin-2-yl)phenol
Appearance Off-white solid
CAS # 371935-74-9
Molecular Formula C₁₉H₁₆N₄O₃
Molecular Weight 348.36
Purity ≥98% by HPLC
Solubility DMSO (50 mM)
SMILES C1COCCN1C2=NC(=NC3=C2OC4=C3C=CC=N4)C5=CC(=CC=C5)O
InChi InChI=1S/C19H16N4O3/c24-13-4-1-3-12(11-13)17-21-15-14-5-2-6-20-19(14)26-16(15)18(22-17)23-7-9-25-10-8-23/h1-6,11,24H,7-10H2
InChi Key TUVCWJQQGGETHL-UHFFFAOYSA-N
PubChem CID 9884685
MDL Number MFCD11983145
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

A cell-permeable, ATP-competitive inhibitor of phosphatidylinositol 3-kinase (PI3K) family members with selectivity toward DNA-PK, PI3K (p110α), and mTOR. The IC₅₀ values are 2, 8, 20, 26, 48, 83, 88, 150 nM for DNA-PK, p110α, mTORC1, PI3-KC2β, p110δ, mTORC2, p110β, and p110γ, respectively. Inhibits growth of human tumor xenografts in mice in vivo.


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Jacque et al., BAFF activation of the ERK5 MAP kinase pathway regulates B cell survival. J. Exp. Med., Jun 2015; 212: 883 - 892.15604.
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