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Phytosphingosine

An apoptosis inducer
Catalog #: 2426
SKU-Size Size Price Qty
2426-50 50 mg
$95.00
2426-250 250 mg
$375.00
More Sizes Get Quote

Product Details

Alternate Name 4-Hydroxysphinganine, D-Ribo-1,3,4-trihydroxy-2-aminooctadecane, D-Ribo-2-aminooctadecane-1,3,4-triol, PHS
Appearance White solid
CAS # 554-62-1
Molecular Formula C₁₈H₃₉NO₃
Molecular Weight 317.51
Purity ≥98% by TLC
Solubility EtOH (~ 2 mg/ml)
SMILES CCCCCCCCCCCCCCC(C(C(CO)N)O)O
InChi InChI=1S/C18H39NO3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-17(21)18(22)16(19)15-20/h16-18,20-22H,2-15,19H2,1H3/t16-,17+,18-/m0/s1
InChi Key AERBNCYCJBRYDG-KSZLIROESA-N
PubChem CID 122121
MDL Number MFCD06804643
Handling Protect from air and moisture
Storage Conditions -20 ̊C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Phytosphingosine is a phospholipid structurally similar to Sphingosine (Cat. No. 2425). The physiological roles of phytosphingosine are largely unknown. Phytosphingosine induces apoptosis in human T-cell lymphoma and non-small cell lung cancer cells, and induces caspase-independent cytochrome c release from mitochondria. In the presence of caspase inhibitors, phytosphingosine-induced apoptosis is almost completely suppressed, suggesting that phytosphingosine-induced apoptosis is largely dependent on caspase activities.


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