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Phospho-VEGFR2 (Tyr-1214) Antibody

Polyclonal antibody to detect VEGFR2 (phospho-T1214) in human samples.
Catalog #: A1043
$295.00

Product Details

Cat # +Size A1043-100
Size 100 µg
Antibody Target KDR
Alternate Name VEGFR-2, FLK-1, KDR, CD309
Host Rabbit
Antibody Type Polyclonal
Isotype Rabbit IgG
Immunogen Synthetic peptide
Accession # P35968
Gene ID 3791
Appearance Colorless liquid
Concentration 1 mg/ml
Formulation 100 ug (1mg/ml) of antibody in 0.01M Tris-HCl, pH 8.0, 0.15M NaCl, and 0.02% sodium azide.
Purification Affinity purified rabbit IgG using protein G
Species Reactivity Human
Application WB, Immunoblot, ELISA
Application & Usage Western blot, Immunoblot: 0.5-2 μg/ml, ELISA
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFC and VEGFD. Plays an essential role in the regulation of angiogenesis, vascular development, vascular permeability, and embryonic hematopoiesis. Promotes proliferation, survival, migration and differentiation of endothelial cells. Promotes reorganization of the actin cytoskeleton. Isoforms lacking a transmembrane domain, such as isoform 2 and isoform 3, may function as decoy receptors for VEGFA, VEGFC and/or VEGFD. Isoform 2 plays an important role as negative regulator of VEGFA- and VEGFC-mediated lymphangiogenesis by limiting the amount of free VEGFA and/or VEGFC and preventing their binding to FLT4. Modulates FLT1 and FLT4 signaling by forming heterodimers. Binding of vascular growth factors to isoform 1 leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate and the activation of protein kinase C


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