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Phospho-VAV3 (Tyr173) Antibody

Polyclonal antibody to detect endogenous levels of VAV3 (Tyr173) in human and mouse samples
Catalog #: A1713

In stock

$395.00

Product Details

Cat # +Size A1713-100
Size 100 µl
Antibody Target Guanine nucleotide exchange factor VAV3
Alternate Name Guanine nucleotide exchange factor VAV3, VAV-3
Host Rabbit
Antibody Type Polyclonal
Isotype IgG
Appearance Colorless liquid
Concentration 1mg/ml
Formulation In phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Affinity purified
Species Reactivity Mouse, Human
Application Western Blotting, ELISA
Application & Usage WB 1:500-1:2000, ELISA (peptide) 1:20000-1:40000
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Exchange factor for GTP-binding proteins RhoA, RhoG and, to a lesser extent, Rac1. Binds physically to the nucleotide-free states of those GTPases. Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly (By similarity). May be important for integrin-mediated signaling, at least in some cell types. In osteoclasts, along with SYK tyrosine kinase, required for signaling through integrin alpha-v/beta-1 (ITAGV-ITGB1), a crucial event for osteoclast proper cytoskeleton organization and function. This signaling pathway involves RAC1, but not RHO, activation. Necessary for proper wound healing. In the course of wound healing, required for the phagocytotic cup formation preceding macrophage phagocytosis of apoptotic neutrophils. Responsible for integrin beta-2 (ITGB2)-mediated macrophage adhesion and, to a lesser extent, contributes to beta-3 (ITGB3)-mediated adhesion. Does not affect integrin beta-1 (ITGB1)-mediated adhesion


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