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Product Details
| Size | 100 µl |
|---|---|
| Antibody Target | Phospho TGFBR2 (Ser225) |
| Alternate Name | TGF-beta receptor type-2; TGFR-2; TGF-beta type II receptor; Transforming growth factor-beta receptor type II; TGF-beta receptor type II; TbetaR-II |
| Host | Rabbit |
| Antibody Type | Polyclonal |
| Isotype | IgG |
| Accession # | P37173 |
| Gene ID | 7048 |
| Appearance | Colorless liquid |
| Formulation | In 0.42% Potassium phosphate; 0.87% NaCl; pH 7.3; 30% glycerol; and 0.01% sodium azide |
| Purification | Affinity purified |
| Species Reactivity | Porcine, Rat, Rabbit, Mouse, Human |
| Application | Western Blotting |
| Application & Usage | WB 1:500 - 1:1000 |
| Handling | The antibody solution should be gently mixed before use. |
| Storage Conditions | -20ºC |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
The protein encoded by this gene is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with TGF-beta receptor type-1, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of genes related to cell proliferation, cell cycle arrest, wound healing, immunosuppression, and tumorigenesis. Mutations in this gene have been associated with Marfan Syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors. Alternatively spliced transcript variants encoding different isoforms have been characterized.
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