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Phospho-Stat2 Antibody

based on 1 citations in multiple journalsPhospho-Stat2 Antibody14.1 4
Catalog #: 3469
$325.00

Product Details

Cat # +Size 3469-100
Size 100 µg
Antibody Target Phospho-STAT2
Host Rabbit
Antibody Type Polyclonal
Isotype Rabbit IgG
Immunogen Synthetic peptide corresponding to resides around amino acid 686 of mouse Stat2
Accession # NP_064347
Gene ID 20847
Appearance Colorless liquid
Concentration 0.5 mg/ml
Formulation 100 µg (0.5 mg/ml) immunoaffinity purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 50% glycerol, 1% BSA, and 0.02% thimerosal.
Purification Affinity purified
Species Reactivity Human, mouse
Application Western blot
Application & Usage Western blotting (1-4 µg/ml). However, the optimal concentrations should be determined individually. The antibody recognizes ~113 kDa phosphorylated Stat2 (Tyr689) of human and mouse origins. Reactivity to other species has not been tested.
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Membrane receptor signaling by various ligands induces activation of Jak kinases which then leads to tyrosine phosphorylation of the various Stat transcription factors. Stat1 and Stat2 are induced by IFN-α and form a heterodimer which is part of the ISGF3 transcription factor complex. Althoμgh early reports indicate Stat3 activation by EGF and IL-6, it has been shown that Stat3β appears to be activated by both while Stat3α is activated by EGF, but not by IL-6. Highest expression of Stat4 is seen in testis and myeloid cells. IL-12 has been identified as an activator of Stat4. Stat5 is activated by prolactin and by IL-3. Stat6 is involved in IL-4 activated signaling pathways.


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Katsoulidis E et al (2008) J. Biol. Chem. 10.1074/jbc.706816200.
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