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Phospho SMAD2 (Ser465) Antibody

Affinity purified rabbit polyclonal antibody to detect phosphorylation of Smad2 at Ser465 in human, mouse, rat, bovine, chicken, monkey, porcine, rabbit, sheep and zebrafish samples
Catalog #: A1950
$285.00

Product Details

Size 100 µl
Antibody Target Phospho SMAD2 (Ser465)
Alternate Name MADH2; MADR2; Mothers against decapentaplegic homolog 2; MAD homolog 2; Mothers against DPP homolog 2; JV18-1; Mad-related protein 2; hMAD-2; SMAD family member 2; SMAD 2; Smad2; hSMAD2
Host Rabbit
Antibody Type Polyclonal
Isotype IgG
Immunogen KLH-conjugated synthetic peptide targeting a sequence within the C-term region of human SMAD2
Accession # Q15796
Gene ID 4087
Appearance Liquid
Formulation In 0.42% Potassium phosphate; 0.87% NaCl; pH 7.3; 30% glycerol; and 0.01% sodium azide
Purification Affinity purified
Species Reactivity Porcine, Rabbit, Bovine, Sheep, Zebrafish, Mouse, Rat, Chicken, Monkey, Human
Application Western Blotting, Immunohistochemistry (IHC)
Application & Usage WB 1:500 - 1:1000, IHC 1:100 - 1:200
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Smads are a group of intracellular proteins that act as signal transducers for the members of TGF-beta superfamily. Based on their roles, Smads are categorized in three groups: receptor regulated (R-Smads) which include Smad 1,2,3,5 and 8; co-regulatory Smads, which includes only Smad4 and inhibitory Smads (I-Smads), which includes Smad6 and 7. When TGF-beta superfamily serine/threonine kinase receptors are activated, this leads to phosphorylation of R-Smads, which then forms a heteromeric complex with co-Smad (Smad4) and as a result, this complex translocates to the nucleus and regulate gene expression of several downstream targets in association with other proteins. I-Smads, on the other hand, do not allow the R-Smads to form a heteromeric complex with co-Smads, thus disrupting the TGF-beta signaling pathway.


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