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Phospho-Retinoic Acid Receptor alpha (Ser77) Antibody

Polyclonal antibody to detect endogenous levels of Phospho-Retinoic Acid Receptor alpha (Ser77)
Catalog #: A1723

In stock

$395.00

Product Details

Cat # +Size A1723-100
Size 100 µl
Antibody Target RARA
Alternate Name Retinoic acid receptor alpha, RAR-alpha, Nuclear receptor subfamily 1 group B member 1, RARA, NR1B1
Host Rabbit
Antibody Type Polyclonal
Isotype IgG
Accession # P10276
Gene ID 5914
Appearance Colorless liquid
Concentration 1mg/ml
Formulation In phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02% sodium azide and 50% glycerol
Purification Affinity purified
Species Reactivity Rat, Mouse, Human
Application Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC), Western Blotting
Application & Usage WB 1:500-1:2000 IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA (peptide) 1:20000-1:40000
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation, chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation


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