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Phospho-Retinoblastoma (Thr826) Antibody

Polyclonal antibody to detect Phospho-Retinoblastoma (Thr826)
Catalog #: A1733

In stock

$395.00

Product Details

Cat # +Size A1733-100
Size 100 µl
Antibody Target Retinoblastoma
Alternate Name Retinoblastoma-associated protein, p105-Rb, pRb, Rb, pp110, RB1
Host Rabbit
Antibody Type Polyclonal
Isotype IgG
Accession # P06400
Gene ID 5925
Appearance Colorless liquid
Concentration 1mg/ml
Formulation In phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Affinity purified
Species Reactivity Rat, Mouse, Human
Application Immunofluorescence (IF), Immunocytochemistry (ICC), Western Blotting, ELISA
Application & Usage WB 1:500-1:2000 IF/ICC 1:100-1:500, ELISA (peptide) 1:20000-1:40000
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Key regulator of entry into cell division that acts as a tumor suppressor. Promotes G0-G1 transition when phosphorylated by CDK3/cyclin-C. Acts as a transcription repressor of E2F1 target genes. The underphosphorylated, active form of RB1 interacts with E2F1 and represses its transcription activity, leading to cell cycle arrest. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation.


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