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Phospho RET (Tyr1062) Antibody

Affinity purified rabbit polyclonal antibody to detect phosphorylation of RET at Tyr1062 in human, mouse, rat and monkey samples
Catalog #: A1978
$325.00

Product Details

Size 100 µl
Antibody Target Phospho RET (Tyr1062)
Alternate Name CDHF12; CDHR16; PTC; RET51; Proto-oncogene tyrosine-protein kinase receptor Ret; Cadherin family member 12; Proto-oncogene c-Ret
Host Rabbit
Antibody Type Polyclonal
Isotype IgG
Accession # P07949
Gene ID 5979
Appearance Colorless liquid
Formulation In 0.42% Potassium phosphate; 0.87% NaCl; pH 7.3; 30% glycerol; and 0.01% sodium azide
Purification Affinity purified
Species Reactivity Rat, Monkey, Mouse, Human
Application Immunohistochemistry (IHC), Immunofluorescence (IF), Western Blotting
Application & Usage WB 1:500 - 1:1000, IHC 1:100 - 1:200, IF 1:100 - 1:500
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

This gene encodes a transmembrane receptor and member of the tyrosine protein kinase family of proteins. Binding of ligands such as GDNF (glial cell-line derived neurotrophic factor) and other related proteins to the encoded receptor stimulates receptor dimerization and activation of downstream signaling pathways that play a role in cell differentiation, growth, migration and survival. The encoded receptor is important in development of the nervous system, and the development of organs and tissues derived from the neural crest. This proto-oncogene can undergo oncogenic activation through both cytogenetic rearrangement and activating point mutations. Mutations in this gene are associated with Hirschsprung disease and central hypoventilation syndrome and have been identified in patients with renal agenesis.


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