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Phospho-PKC ζ (Thr 410) Antibody

Polyclonal antibody to detect Phospho-PKC ζ (Thr 410) in human, mouse and rat samples.
Catalog #: A1130
$285.00

Product Details

Cat # +Size A1130-100
Size 100 µl
Antibody Target PRKCZ
Alternate Name PRKCZ; PKC2; Protein kinase C zeta type; nPKC-zeta
Host Rabbit
Antibody Type Polyclonal
Isotype Rabbit IgG
Immunogen Synthesized peptide derived from human PKC ζ around the phosphorylation site of Thr 410.
Accession # Q05513 (Human); Q02956 (Mouse); P09217 (Rat)
Gene ID 5590 (Human); 18762 (Mouse); 25522 (Rat)
Appearance Colorless liquid
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide
Purification Affinity-purified using epitope specific immunogen.
Species Reactivity Human, mouse and rat
Application WB, IHC, IF, ELISA
Positive Control WB: 823, Hela, PC-3, MCF-7, 22RV1 cell lysate
Application & Usage WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:20000
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Calcium- and diacylglycerol-independent serine/threonine-protein kinase that functions in phosphatidylinositol 3-kinase (PI3K) pathway and mitogen-activated protein (MAP) kinase cascade, and is involved in NF-kappa-B activation, mitogenic signaling, cell proliferation, cell polarity, inflammatory response and maintenance of long-term potentiation (LTP). Upon lipopolysaccharide (LPS) treatment in macrophages, or following mitogenic stimuli, functions downstream of PI3K to activate MAP2K1/MEK1-MAPK1/ERK2 signaling cascade independently of RAF1 activation. Required for insulin-dependent activation of AKT3, but may function as an adapter rather than a direct activator. Upon insulin treatment may act as a downstream effector of PI3K and contribute to the activation of translocation of the glucose transporter SLC2A4/GLUT4 and subsequent glucose transport in adipocytes.


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